Effect of Rohitakarista (RHT), an ayurvedic formulation, on the lipid profile of rat plasma after chronic administration

Rohitakarista (RHT), a popular Ayurvedic formulation, is the preparation of Tecomella undulate with other medicinal plants. In this study, the lipid profile of rats’ plasma was studied after chronic administration of RHT usually used in the disease of spleen, abdomen and localized abdominal swelling or tumor. The animal was albino rats (Rattus novergicus: Sprague-Dawley strains) and RHT was administered per oral route at a dose of 100mg/kg body weight, once daily, up to 46 days for all the experiments. Forty rats, equally of both sexes, were randomly grouped into four where one male and one female group were used as control and other groups were used as test. In both of the male and female rats there was a statistically very high significant decrease in the Triglycerides (p=0.001***). On the contrary, a statistically very highly significant increase in the total cholesterol (p=0.001***), VLDL (p=0.001***) and HDL (p=0.001***) was noted. Similar results were observed in case of female rats. Also the increase in LDL (p=0.028*) was statistically significant for both of the sexes of RHT treated rats.